Quick Overview for DDK-1 protein (Fc Tag) (ABIN7319907)
抗原
蛋白类型
宿主
资源
纯度
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标记
- Fc Tag
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原理
- Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)
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序列
- Thr32-His266
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产品特性
- Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a Fc tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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DDK-1 protein (His tag,Biotin)
宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
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说明
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60-80 kDa
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- DDK-1
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背景
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Background: Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Synonym: Dickkopf-related protein 1, Dickkopf-1, Dkk-1
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分子量
- 52.7 kDa
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UniProt
- O94907
抗原
-
